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There remain critical gaps in our understanding of the emergence of functional biopolymers
in the origins of Earth’s biosphere. Extant proteins, evolved over millions of years, carry out
an impressive array of responsibilities, from catalysis and molecular recognition to motility
and compartmentalization. One of the major goals of our lab is to investigate the possible
origins of advanced enzymatic functions from folds of short peptide based paracrystalline
phases. 1-2 Further, we are excited about understanding the non-equilibrium structures of living
systems. 3-8 I will show our recent discoveries of simple chemical systems that can be
substrate-driven to access higher energy self-assembled states, just as seen in natural
microtubules. Further, I will attempt to sketch our aims of developing self-assembled
autonomous materials that can show temporal control of functions . 3,8
References and Notes:
1. B. Sarkhel, A. Chatterjee and D. Das*. J. Am. Chem. Soc. 2020 142 4098-4103
2. A. Chatterjee, A. Reja, S. Pal and D.Das* Chem. Soc. Rev., 2022, 51, 3047-3070
3. S.P. Afrose, C. Mahato, P. Sharma, L. Roy, and D. Das*. J. Am. Chem. Soc. 2022, 144, 673-
678.
4. S. Pal, A. Reja, S. Bal, B. Tikader and D. Das* Angew. Chem. Int. Ed. 2022, e202111857.
5. A. Chatterjee, S. Ghosh, C. Ghosh and D.Das* Angew. Chem. Int. Ed. 2022, e202201547.
6. S. Goswami, A. Reja, S. Pal, A. Singh, and D. Das* *. J. Am. Chem. Soc. 2022 144 accepted
article
7. S. Bal, K. Das, S. Ahmed and D.Das* Angew. Chem. Int. Ed. 2019 58 244
8. H. S. Azevedo, S. L. Perry, P. A. Korevaar, D. Das. Nature Chemistry 2020, 12, 793-794 |