| Details: |
New strategies have been developed for the stereoselective synthesis of substituted piperidines and pyrones with high structural
diversity via the regioselective addition of 1,3-dicarbonyl dianion to N-activated imines and aldehydes.1
Further a domino-iminoaldol-aza-Michael,
a domino-imino-aldol-aza-Michael-imino-aldol, a domino-Michael-Michael and a domino-aldol-aldol reaction
sequences have been developed for the stereoselective construction 2,6-disubstituted piperidines and highly functionalized
quaternary carbon center containing cyclohexanone derivatives.2
Enolates from amino acid derivatives have been utilized for the
synthesis of α,β-diamino acid derivatives, and functionalized aziridines in enantioselective form.3
Post-Doctoral Research I: Synthetic and Mechanistic Study of SmI2 Mediated Radical Reactions
In SmI2 mediated reactions HMPA is most effective to enhance the reduction potential of SmI2, but for the conversion of radical
anion to radical, a proton source is compulsory. These two properties have been merged together to introduce a new
phosphoramide ligand (HOMPA) in which one of the methyl groups of HMPA was substituted by a CH2-CH2-OH unit. The role of
HOMPA and its mechanistic understanding in SmI2 mediated radical reactions was extensively studied.4
Post-Doctoral Research II: Asymmetric Hydrovinylation Reactions Catalyzed Ru and Rh Complexes
New catalyst systems using Ru and Rh containing metal complexes have been developed for the asymmetric installation of
ethylene gas across an unactivated double bond of vinyl arenes. A series of chiral bis-phosphine ligands have been studied in the
presence of various activators. The hydrovinylated products were obtained in excellent yields with moderate to good |