| Details: |
The development of multi-functional ligands for positron emission tomography (PET), combined with optical and/or magnetic resonance imaging is a fast developing field. Important requirements for promising ligands are relatively fast and efficient complexation, high complex stability with specific radiometal ions and ligands, which are easy to couple to biological vectors, nanoparticles and/or fluorescence probes. Ligands based on 3,7-diazabicyclo[3.3.1]-nonane (bispidine) form very stable transition metal complexes, in particular with CuII; formation kinetics, metal ion selectivities and the variability in terms of donor groups and functionalization makes these ligands an ideal platform for multimodal imaging. Bispidine derivatives for radiopharmaceutical applications with CuII and various lanthanides, actinides and main group metal ions, their functionalization as well as the related coordination chemistry, biodistribution studies and applications in tumor imaging will be reported. |