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The present talk will consist of three modern topics of interest. The first part will be presented on the catalytic
generation of silicon based copper-(I) reagents from silicon pronucleophiles. The reactivity and selectivity of two
organometallic species such as (PhMe2Si)2Zn and PhMe2Si–Bpin will also be discussed. The synthetic application
of the methodologies and the synthesis of new materials will be highlighted. The second part of the talk will be
focused on the development of a mild and robust direct C–H functionalization strategy to the synthesis of axially
chiral biaryls at ambient temperature with catalytic amount of Pd(OAc)2. Such an efficient and stereoselective
transformation occurs through an original dynamic kinetic resolution pathway enabling the conversion of
diastereomeric mixtures of nonprefunctionalized substrates into atropisomerically pure, highly substituted biaryl
scaffolds. The main feature of this transformation is the use of an enantiopure sulfoxide as both chiral auxiliary
and traceless directing group. The third part of the talk will consist of metal-free processes. In this part, a facile
transformation of furans into silicon functionalized synthetic intermediates, by tris(pentafluorophenyl)borane–
catalyzed cascade hydrosilylation processes under transition metal-free conditions will be discussed. In addition,
mechanistic studies with synthetic applications will be presented in details. Finally, the scope and mechanistic
studies of B(C6F5)3-catalyzed ring-closing of alkene precursors to small molecules with hydrosilane will be
highlighted. |