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Nanoparticles that are capable of targeting a specific cell type or a specific organelle in a certain cell population can be of tremendous therapeutic relevance. Meticulously designed of nano-constructs and drug payload can impartspatio-temporal control on the therapeutic potential. Spatial control enables site-specific activity of a drug and thereby minimizing off-target effects. This can be achieved by the use of targeting ligands and smartly engineered drug delivery vehicles. Temporal control provides an additional tool by means of which one can switch “on” or “off” the therapeutic activity of a drug.
This lecture will encompass a journey from designing small molecules for potential chemotherapeutic applications to developing nano-constructs for a variety of biological applications. It all started with designing of small oxovanadium(IV) complexes for their potential use as photochemotherapeutic agents. Among all those, trans-dichlorooxovanadium(IV) complexes of terpyridine ligands were particularly interesting as they were found to cross-link DNA in an inter-strand fashion upon photoactivation. A section of the lecture will discuss cisplatin prodrugs and their delivery using mitochondria-targeted nanoparticle platforms. The later half of the talk will showcase other vivid biological applications of nanoparticles like Blood-Brain Barrier (BBB) penetrating nanoparticles, polymer-lipid hybrid nanoparticles for therapeutic and diagnostic applications in atherosclerosis and iron oxide based nano-tools for magnetic isolation of mitochondria. Towards the end, some new directions will be discussed that might be interesting to explore in future.
References:
1. Banik, B. et.al., Trans-dichlorooxovandium(IV) complex as a novel photoinducible DNA interstrand cross-linker for cancer therapyCarcinogenesis, 37 (2), 145-156.
2. Banik, B. et.al., New formulation of old aspirin for better deliveryChem. Commun., 52, 140-143.
3. Banik, B. et.al., Mito-magneto: A tool for nanoparticle mediated isolation of mitochondriaNanoscale, 8, 19581-19591.
4. Banik, B. et.al., Centrifugation Free Magnetic Isolation of Functional Mitochondria Using Paramagnetic Iron Oxide Nanoparticles Current Protocols in Cell Biology, September 2017, 25.4.1-25.4.20.
3. Marrache, S. et.al.,Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis. Proceedings of the National Academy of Sciences, 2013. 110(23): p. 9445-9450.
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