| Description: | [DPS Seminar] Dr. Raja Paul (IACS, Kolkata) -- A mechanistic model for nuclear migration and chromosome segregation in budding yeast during mitosis |
| Date: | Wednesday, Mar 21, 2018 |
| Time: | 3 p.m. - 4 p.m. |
| Venue: | G02, Lecture Hall Complex |
| Details: | Precise segregation of DNA during mitosis is critical to maintain genome stability and prevent erroneous cell division. A bipolar spindle pulls the sister chromatids to opposite ends of the cell upon chromosomal separation, leading to the formation of two daughter cells with exactly the same chromosome number. While mammalian cells divide via open mitosis (nuclear envelop breaks down), chromosome segregation in budding yeast cells occur within the nucleus known as closed mitosis. In closed mitosis, the entire nucleus and the kinetochores cluster migrates into the daughter bud to facilitate high fidelity chromosome segregation. Further, kinetochore clustering and nuclear migration requires biased movement of microtubules plus end along the cell cortex. Our computer model, correctly predicts experimentally observed time-scales of nuclear migration and spindle assembly with error statistics. |
| Calendar: | Seminar Calendar (entered by anandamohan) |