| Description: | [DBS Seminar] Vivek Rai (Scentist D,Institute of Life Sciences) -- Biology and Regulation of Atx-LPA and Mitochondrial p32 in Cell Differentiation and Cancer |
| Date: | Wednesday, May 23, 2018 |
| Time: | 1:45 p.m. - 3:15 p.m. |
| Venue: | G08, Lecture Hall Complex |
| Details: | Elucidation of the mechanisms underlying immune cell differentiation, proliferation and functions in steady state and upon pathogen invasion or in diseases is fundamental to the understanding of immune system function. A major focus in our lab is to study how evolutionarily ancient signaling modules are rewired to regulate immune cells in homeostasis, tumor microenvironment and metastasis. We revealed an unexpected function of LPA that converts murine monocytes into macrophages in mice and humans. Using genetically engineered mouse models, we have found that Atx-LPA via Akt pathway play crucial roles in these macrophages development. Transcriptome analysis further reveals that PPARī§ is the key transcriptional regulator in the development of LPA induced macrophages. These findings identify unseen role for LPA in regulating innate immune system. We are further involved with immune cells and specifically the control of macrophage and T cell development in homeostasis and tolerance. Our other findings suggest critical regulation of Atx-LPA and mitochondrial p32 in muscle development and muscle repair. Further we aim to unravel the molecular mechanisms of such regulation, and to establish the functions of these signaling pathways in respect to ATX-LPA and mitochondrial p32 in inflammation and cancer and moreover we are targeting immune cells as our approach towards cancer immunotherapy. |
| Calendar: | Seminar Calendar (entered by arun.ds) |