| Description: | [Seminar] Aakash Bhattacharyya (University of Texas, San Antonio, TX, USA) -- HIV restriction via a scorched earth strategy – a case study of SAMHD1 |
| Date: | Friday, Jul 13, 2018 |
| Time: | 3 p.m. - 4 p.m. |
| Venue: | G02, Lecture Hall Complex |
| Details: | The HIV life cycle involves subversion of the host cell’s cytoskeletal machinery and metabolic reservoirs to replicate the viral genome and package it in the form of new virions. Certain cells of the immune system display the capability to restrict HIV infection. They do so by the novel strategy of denying the virus the deoxynucleotide triphosphates that are needed to reverse transcribe the viral genome. This depletion of cellular dNTP reservoir levels has been termed a Scorched Earth strategy – and is effected by the enzyme SAMHD1. In this talk, I will discuss the structure, dynamics and function of SAMHD1. This protein functions as an allosterically triggered tetramer. The assembly, lifetime and regulation of this protein are all open questions which we have addressed using a wide array of biophysical techniques to develop an operational model for this enzyme. |
| Calendar: | Seminar Calendar (entered by rangeet) |