[CAFM seminar] Prof. Tapas K. Kundu (Molecular Biology and Genetics Unit, JNCASR Bangalore and Director, CSIR-Central Drug Research Institute, Lucknow)

Description:	[CAFM seminar] Prof. Tapas K. Kundu (Molecular Biology and Genetics Unit, JNCASR Bangalore and Director, CSIR-Central Drug Research Institute, Lucknow) -- Targeting of therapeutic molecules in brain: Implications in neurodegenerative disorder, Cancer and Infectious diseases
Date:	Friday, Sep 14, 2018
Time:	3 p.m. - 5:30 p.m.
Venue:	TRC Auditorium (2nd Floor)
Details:	Glucose derived carbon nanospheres (CSP)1 are cell permeable, self-fluorescent and possess unique ability to cross blood brain barrier. By employing CSP, we delivered a small molecule activator of master epigenetic enzymes, p300/CBP and induced acetylation of histones which resulted in adult neurogenesis and thereby activation of long term memory in mice2 . This system could also be used to recover the memory deficiency in Alzheimer’s disease model mice almost completely. 3 Delivery of anti-neoplastic therapeutics for glioma could also be done successfully using CSP. Presently we are actively working on the delivery of antibiotics for brain infection. References: 1. Selvi BR, et al., Nano Lett. 2008, 8, 3182-8. 2. Chatterjee S# , et al., J Neurosci.2013,33,10698-712. 3. Chatterjee S# , et al., EMBO. Mol. Med. (In Press). 4. Elechalawar C. K# , et al., (Manuscript under revision).
Calendar:	Seminar Calendar (entered by sds)