| Description: | [DCS Visitor's Seminar] Dr. Tatini Rakshit (DST Inspire Faculty, Centre for Nanotechnology, IIT Guwahati) -- Applications of Scanning Probe Methods in Biology at the Nanoscale |
| Date: | Wednesday, Sep 12, 2018 |
| Time: | 5 p.m. - 6:30 p.m. |
| Venue: | TRC Auditorium (2nd Floor) |
| Details: | Bio-nanotechnology is a rapidly growing field at the intersections of nanoscience, biology and engineering. Advancement in this field strongly depends on the development and suitable applications of single molecule detection methods (SMD), e.g. Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM). Evolving from an imaging technique to a multi-functional toolbox, AFM based force spectroscopy is increasingly used to study the mechanisms of important biological events. In this presentation I would briefly talk about metallo-protein based bio-electronics and structural aspects protein-protein assemblies using AFM force spectroscopy. Then I would discuss how AFM imaging and image analyses contribute towards understanding the mechanism of GPCR mediated signaling events. As a concluding part I would show recent results on single-molecule level biophysical characterization on centromeric nucleosomes. Finally, I would present my proposed research plans related to single-molecule investigations on extracellular vesicles from bio-fluid which can serve as a potential noninvasive diagnostic tool. |
| Calendar: | Seminar Calendar (entered by sds) |