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Heat and high energy chemicals (like ATP) drive several biological processes needed to sustain life. My work is about the fundamental powering logic that cells employ to generate heat and synthesize ATP. Over the past two decades, I have focused on heme/flavin redox enzymology and this has enabled me to propose a fundamentally original theory for explaining a bevy of metabolic/physiological phenomena involving these enzymes in routine biological/ecological systems. The new explanation is called "murburn" concept (abstracted from mured/closed burning) concept, connoting a "molecule-unbound ion-radical" interactive paradigm, involving a new redox enzymatic mechanism. The prevailing perceptions consider that proton-pumps and specific electron transport chains lead to a chemiosmosis-based trans-membrane potential, which aids in rotary ATP-synthesis. The new theory deems diffusible reactive oxygen species (DROS) as quintessential catalytic requisites for mitochondrial phosphorylations. The new perspective renders several textbook ideas redundant and better explains molecular evolution of life, structure-function correlations of respiratory proteins, action of inhibitors/toxins/uncouplers, etc.
References: https://scholar.google.co.in/citations?hl=en&user=gvBtBHYAAAAJ&view_op=list_works&sortby=pubdate |