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Medicine is a natural companion of mankind of the present era for mere survival from the deadly diseases in the ever-increasing polluted environments. Hence, in recent years, the major focus of pharmaceutical, medicinal and biophysical research has been navigated in exploring and developing new and simple avenues to enhance the efficacy of the administered drugs on one hand and to get rid of, or at least reduce, the toxic side effects of the excess drugs accumulated in our body on the other. A potential approach to amplify the efficacy of the administered drug is to develop proficient targeted drug delivery systems (DDSs). Simple but prospective strategies on enhancing the efficacy of drugs/bioactive molecules exploiting various DDSs like micelles, cyclodextrins, liposomes etc. to serve the purpose of targeted delivery towards DNA, by endogenous and/or exogenous means, have been developed. Improved bio-availability and solubilization of ionic drugs within the less polar target regions from the bulk aqueous phase has also been achieved through the introduction of some physiologically permissible salts. On the other context, recent in vitro and in vivo studies demonstrate a simple strategy for easy removal of the excess adsorbed drug molecules from the cell membranes/lipid bilayers by exploiting health-amiable supramolecular assemblies like cyclodextrins.
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