| Description: | [Inst talk] Dr. Ashish Ranjan (Center for Veterinary Health Sciences, Oklahoma State University) -- Role of focused ultrasound, novel adjuvants, and nanoparticles in cancer chemo-immunotherapy |
| Date: | Friday, Oct 25, 2019 |
| Time: | 3 p.m. - 4 p.m. |
| Venue: | Meghnad Saha Lecture Theatre |
| Details: | Magnetic resonance and ultrasound (US)-guided focused ultrasound (FUS) is a clinically relevant therapeutic technology that provides a spatially accurate mechanical stress and heating of a solid tumor, without causing collateral toxicity to healthy tissues. FUS can also promote immunogenic recognition of tumor cells by aiding the translocation of damage associated membrane proteins. Our research has shown that FUS-induced local heating and stress and combination with lipid-based nanoparticles can modify the tumor microenvironment to impart several benefits including enhanced solid cancer chemotherapy, tumor antigen release, and anti-tumor immunity compared to conventional therapy in pre-clinical models. In this seminar, I will discuss the concepts and techniques, and also provide examples of clinical translation in canine cancer treatment. |
| Calendar: | Seminar Calendar (entered by arnab.gupta) |