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My lecture will overview cocrystals as an alternative approach to designing solid forms of pharmaceutical materials for development within the pharmaceutical materials science area. Key is the identifying solid forms which show characteristics of stability, solubility (bioavailability), compressibility and so on - especially for the development of tablets. An area of current interest is in cocrystals - which requirement the formation of an ordered crystalline lattice containing two or more molecules in an ordered array. This approach extends the use of polymorphism as an engineering tool.
Mechanochemistry is a useful approach to screening for whether two molecules will in fact crystallise together rather than separately during crystallisation. The approach is simple in concept but has many variables to make it fully useful and reliable. the talk I will illustrate some of these points, highlighting its advantages as well as some of the issues involved. |