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The pharma industries are compelled by the environment protection agency to thrive for sustainable development due to the cumulative footprint of the adverse effect of chemical processes on the environment. Thus, the chemistry research is under the increasing influence of green chemistry tools that put emphasis on the necessity to enrich the medicinal chemists’ tool box furthering synthetic research for concise and dependable access to new areas of chemical space and improvements to tried and tested (and widely employed) methodologies, where clear deficiencies in areas such as atom economy, safety cost effectiveness, and scalability are identified.
The use of volatile organic solvents (VOSs) is the major contributory factor towards environment damage requiring alternate reaction media for which the attention is focussed on water and ionic liquids (ILs).
However, innovation occupies the centre stage of sustainable development. The present discussion will be on some innovative approaches to adopt aquatic organic reactions through the revelation of the molecular level interaction of water with small organic molecules (reactants) involving supramolecular framework as catalytic species that would promote rational use of water as alternative reaction medium in tuning organic reactions. Another aspect of the discussion will be to demonstrative the non-solvent uses of ILs through unraveling the origin of their catalytic potential and forming the basis of their selection for organo-catalytic applications for diverse organic synthesis.
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