| Description: | [DPS Seminar] Dr. Bhaswar Ghosh (Centre for Computational Natural Sciences, International Institute of Information Technology, Hyderabad) -- Design of a MAPK signaling cascade optimizes information and energy dissipation trade-off -::~::- Join: https://meet.google.com/dhn-dnzp-wnp -::~::- |
| Date: | Wednesday, Feb 24, 2021 |
| Time: | 2 p.m. - 3:30 p.m. |
| Details: | Cellular processes are inherently noisy, and the selection for accurate responses in presence of noise has likely shaped signaling networks. Here we investigate the trade-off between accuracy of information transmission and its energetic cost for a mitogen-activated protein kinase (MAPK) signaling cascade. Our analysis of the pheromone response pathway of budding yeast suggests that dose-dependent induction of the negative transcriptional feedbacks in this network maximizes the information per unit energetic cost, rather than the information transmission capacity itself. We further demonstrate that the energy dissipation within the signaling cascade has a measurable effect on growth fitness, thus likely being subject to evolutionary selection. Considering optimization of accuracy versus the energetic cost of information processing, a concept well established in physics and engineering, may thus offer a general framework to understand the regulatory design of cellular signaling systems. |
| URL: | https://meet.google.com/dhn-dnzp-wnp |
| Calendar: | Seminar Calendar (entered by anandamohan) |