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Abstract: There remain critical gaps in our understanding of the emergence of functional biopolymers in the origins of Earth’s biosphere.
For instance, extant proteins, evolved over millions of years, carry out an impressive array of responsibilities, from catalysis and
molecular recognition to motility and compartmentalization. One of the major goals of our lab is to investigate the possible origins of
advanced enzymatic functions from folds of short peptide based paracrystalline phases.1,2 Further, we are excited in understanding the
non-equilibrium structures of living systems.3-6 The fact that living matter continuously consumes energy to generate and sustain local
order suggests that bioenergetics played critical role in biopolymer evolution that predated the emergence of life. Through my talk, I will
show our recent discoveries of simple chemical systems that can be substrate-driven to access higher energy self-assembled states,
just as seen in Natural microtubules. Further, I will attempt to sketch our aims of developing self-assembled autonomous materials that
can show temporal control of functions.
3,5-8
References: 1. J. Am. Chem. Soc. 2020 142 4098-4103 2. Angew. Chem. Int. Ed. 2020 59 4329-4334 3. Angew. Chem. Int. Ed. 2020, 59, 13506 4.
Angew. Chem. Int. Ed. 2019 58 15783-15787 5. Chemical Science 2019 10 7574-7578 6. Angew. Chem. Int. Ed. 2019 58 244 7. Angew. Chem.
Int. Ed. 2021, 60, 204-209 8. Nature Chemistry 2020, 12, 793-794.
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